";s:4:"text";s:15683:"Severe poisonings may require specific measures: A. The use of endosulfan needs to be strictly regulated and eventually banned worldwide altogether to lower the current morbidity and mortality resulting from this pesticide. The use of endosulfan needs to be strictly regulated and eventually banned worldwide altogether to lower the current morbidity and mortality resulting from this pesticide. Accidental and suicidal poisoning with endosulfan are reported in literature. Fipronil disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride (GluCl) channels.This causes hyperexcitation of contaminated insects' nerves and muscles. We thank our colleagues and staff of Internal Medicine and Critical Care, Medwin Hospitals, India. Singapore Med J. Decomposed rapidly by alkali to generate sulfur dioxide. Endosulfan poisoning: a study of 22 cases J Assoc Physicians India. Endosulfan is highly toxic to fish. Keywords: Endosulfan, histopathology, intradermal, nephrotoxic necrosis. Saudi J Kidney Dis Transpl. Acknowledgement. Singapore Med J. Endosulfan Poisoning in Kasargod, Kerala, India Report of a Fact Finding Mission. Supreme Court gives Kerala 90 days to compensate victims of Endosulfan poisoning. Fipronil is a broad-spectrum insecticide that belongs to the phenylpyrazole chemical family. OBJECTIVES: The objective of the study is to identify the clinical profile of endosulfan poisoning and also to recognise any biochemical parameters which indicate clinical or subclinical dysfunction of organs so that the offending agent can be easily identified in a given case of poisoning and appropriate treatment instituted promptly. Banerjee speculates it could take generations for people and the land in India to recover from endosulfan poisoning. Absorbed from the gut, by the lungs and across skin Fat and fat solvents enhance absorption Most are dechlorinated, oxidized, then conjugated Chief toxic action is on CNS SIGNS & SYMPTOMS To prevent death and to accelerate improvement, the organs that have more apparent histopathological injury should be considered and early and intensive supportive treatment … Results of the toxicity was analyzed statistically13 for the determination of LD 50 of the endosulfan. Observe patients with an apparent nonsignificant and nontoxic exposure in … Endosulfan poisoning caused the hypotension and the abnormalities on electrocardiogram at presentation. Keep the material and the emptied containers away from ground and surface water. Morgan (1989, pp. Treatment of shock, supportive care, … Roberts DM, Dissanayake W, Rezvi Sheriff MH, Eddleston M. Refractory status epilepticus following self-poisoning with the organochlorine pesticide endosulfan. The treatment scheme for the different groups (n = 6) was identical to the scheme shown above except that groups 4 and 7 were omitted. 03/01/2000 - "The objective of the study is to identify the clinical profile of endosulfan poisoning and also to recognise any biochemical parameters which indicate clinical or subclinical dysfunction of organs so that the offending agent can be easily identified in a given case of poisoning and appropriate treatment instituted promptly. Bulletin of the World Health Organization 2003, 81 (11) 789 Pesticide poisoning in Sri Lanka Objectives To assess in a developing Asian country the impact of pesticide regulation on the number of deaths from poisoning. We report 23 cases of endosulfan poisoning. 2004 Sep. 11(7):760-2. … It can cause also life threatening metabolic disturbances. Ratheesh Kundamkuzhi, who works among endosulfan victims, says there are patients in the list getting two monthly pensions - endosulfan pension and the one for differently abled. Decomposed rapidly by alkali to generate sulfur dioxide. Organochlorine poisoning accounts for only a small fraction of pesticide poisoning, but the incidence varies from 1.8% of all poisonings in South Korea to 13.3% in some parts of India. Case Reports. To prevent endosulfan poisoning, the usage of it should be restricted and even prohibited. Mamatha, her family claim, is an endosulfan poisoning victim. If poisoning occurs, call a physician. J Environ Sci Health C13:49–62. The serum amylase levels are generally normal, whereas the lipase and glucose levels are increased. Acute endosulfan poisoning: a retrospective study. Management of endosulfan poisoning is mainly supportive and there is no antidote for it. Fifty-two patients who presented with acute endosulfan poisoning between January 2001 and January 2007 were enrolled in this retrospective study. Agents such as DDT and methoxychlor tend HIGHLIGHTS Only dicofol, endosulfan, lindane still registered for use in U.S. Arch Toxicol 43: 65–68. It was also the chemical that caused an environmental disaster in India in the 1980s and 1990s, when it was aerially sprayed on crops such as cashews. Acute kidney injury in endosulfan poisoning. [17, 18] A study of contamination in the Brazilian population showed adverse effects on … Methods. Decomposed by acid. After recovery the patient became disoriented and agitated. History. Sixteen (30.7%) of the 52 patients died, and 48 patients experienced seizures. In water, it is mainly degraded to endosulfan diol. Prophylactic anticonvulsant therapy for symptomatic patients and aggressive treatment for seizures may limit morbidity, but, no effective antidote is available [Moses V, Peter JV. Despite their widespread use in agriculture during the 1940s to 1960s and the well‐known signs and symptoms of intoxication, the clinical picture in case of poisoning varies. Karatas AD, Aygun D, Baydin A. Characteristics of endosulfan poisoning: a study of 23 cases. 4,8 Seizure du-ration of endosulfan-related SE varies among studies.3-5,8 A recent study reported that median duration of antiepileptic drug (AED) use in endosulfan poisoning was 48.0 hours (range, 29.3-103.5 hours) in non-refractory SE and 48.5 hours (range, 23.8-63.5 hours) in re- The author describes a case of acute poisoning by endosulfan (a chlorinated hydrocarbon insecticide) in an industrial worker, with residual psychiatric syndrome. Endosulfan can be applied by groundboom sprayer, fixed-wing aircraft, chemigation (potatoes only), airblast sprayer, rights-of-way sprayer, low pressure handwand sprayer, high pressure handwand sprayer, backpack sprayer and dip treatment.Regulatory Decomposed by acid. 1992 Feb;40(2):87-8. Management includes decontamination of skin and gastrointestinal tract, supportive care including treatment of status epilepticus, dysrhythmias, and mechanical ventilation. Hum Exp Toxicol 2009;28:309-16] . The health effects of the chemical include neurotoxicity, late sexual maturity, physical deformities, poisoning, among others. We report two cases of acute intentional endosulfan intoxication with cerebral edema and cardiac failure. TY - JOUR T1 - Endosulfan poisoning: a study of 22 cases. INTRODUCTION: Organochloride insecticides are chlorinated cyclic hydrocarbons having molecular weights in the range of 300-550 Da. period after ingestion. In the absence of effective antidotes, restriction of its availability, along with prompt treatment of toxicity, including preemptive anticonvulsant therapy are suggested. Thus, we reported the potential benefits of antioxidant treatment with NAC in endosulfan intoxication. Endosulfan is an organochlorine recognized as an important agent of acute toxicity. Methods. 2004 Sep. 11(7):760-2. Endosulfan pesticide was used widely on crops like cashew, cotton, tea, paddy, fruits and others until 2011, when the Supreme Court banned its production and distribution. istic of acute organochlorine poisoning. The acute phase was manifested by repeated convulsions and impaired consciousness. 2006 Dec. 47(12):1030-2. . Endosulfan Poisoning and the Struggle of the community in Kasaragod to regain life and the living land [click to view] Down to Earth Report [click to view] REPORT ON MONITORING OF ENDOSULFAN RESIDUES IN THE 11 PANCHAYATHS OF KASARAGOD DISTRICT, KERALA [click to view] Endosulfan poisoning is a devastating catastrophe with very high mortality. ... also asked the state to consider setting up a centre to provide lifelong medical treatment to all the victims. Incidence of acute and chronic toxicity with endosulfan poisoning has been reported, and nearly 80 countries have banned its use. See Chlorinated and other halogenated hydrocarbons ... respiratory failure, loss of hair about 3 weeks after poisoning. may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. It can build up in bodies of animals that live in endosulfan contaminated water. Management is mainly supportive as no antidote exists for endosulfan poisoning as yet. Acute Endosulfan poisoning is associated with a high mortality rate in humans, and can exceed 30% [Moon JM, Chun BJ. Management is mainly supportive as no antidote exists for endosulfan poisoning as yet. As there is no antidote available, aggressive supportive treatment remains the mainstay of management. Endosulfan sulfate is expected to occur in the environment as the oxidative degradation product and as the biodegradative product of the pesticide endosulfan. Google Scholar In this retrospective study, the clinical features, course, and outcomes among patients with acute endosulfan poisoning requiring admission to the hospital during an 8 … Incompatible with strong oxidizing and reducing agents. The SC has instructed Kerala government to provide compensation to 5000 victims of Endosulfan poisoning Endosulfan poisoning can cause histological pancreas lesions. Management of acute endosulfan poisoning in an organophosphate poisoning clinic Letter to the EditorM. (c) The emulsifiable concentrate shall consist of technical endosulfan dissolved in suitable solvents, with other necessary formulants added. Treatment of carbamate poisoning is similar to that of organophosphate poisoning in that atropine sulfate injections readily reverse the effects. The victims had held several rounds of agitations such as rallies, sit-ins and hunger strikes in the state capital in 2012, 2013, 2014, 2016 and 2018, seeking the attention of the governments in power. The agitations were organised by the People’s Movement for Endosulfan Victims, formed in 2012. No specific antidotes are available for We thank our colleagues and staff of Internal Medicine and … endosulfan diol are susceptible to photolysis. Go to: Acknowledgement. AU - Singh,N, AU - Singh,C P, AU - Kumar,H, AU - Brar,G K, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez SP - 87 EP - 8 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 40 IS - 2 N2 - Twenty two cases of endosulfan poisoning with their symptomatology are reported. This is best performed in the field. For 20 years, this pesticide—endosulfan—was aerially sprayed on thousands of hectares of hilly cashew plantations in Kasargod. People living in more than 20 gram panchayats in Kasargod district were exposed to the insecticide EPA used modeled Tier 2 estimates of endosulfan and endosulfan sulfate to estimate risk for acute exposures. Taking into account the supported uses of endosulfan, the Agency concluded that residues of endosulfan in drinking water are of concern. Endosulfan is a highly toxic insecticide that produces tonic-clonic convulsions, headache, dizziness and ataxia. We report two cases of acute intentional endosulfan intoxication with cerebral edema and cardiac failure. 1. Acute endosulfan poisoning: a retrospective study. Due to the high progression rates from seizure-related endosulfan poisoning to SE and RSE and the absence of an established treatment for SE-related endosulfan poisoning, physicians should aggressively treat patients who experience a seizure after endosulfan poisoning … Its half-life in water is estimated to be 4 days, but anaerobic conditions and/or a low pH will lengthen the half-life. See Chlorinated and other halogenated hydrocarbons ... respiratory failure, loss of hair about 3 weeks after poisoning. Poisoning by chlorinated hydrocarbon insecticides is well known. The half-life of endosulfan varies from 60 days to 800 days. Despite their widespread use in agriculture during the 1940s to 1960s and the well‐known signs and symptoms of intoxication, the clinical picture in case of poisoning varies. Endosulfan. Endosulfan is an organochlorine recognized as an important agent of acute toxicity. BEKTAS ET AL.To the Editor: Endosulfan has a high toxicity consistent with other members of the family of chlorinated hydrocarbon insecti-cides (1), and may be absorbed via skin, inhalation, and the Endosulfan, Organophosphorus, Poisoning, Salem INTRODUCTION Poison is a substance that causes damage or injury to the body and endangers one’s life due to its exposure by means of ingestion, inhalation or contact (Thomas et al., 2004). One condition is the control of bollworms in cotton crops. Experimental Procedure Proven fertile … The pilot made a full recovery and has remained seizure-free without treatment (Cable & Doherty, 1999). METHODS: In this retrospective study, the clinical features, course, and outcomes among patients with acute endosulfan poisoning requiring admission to the hospital during an 8-year period (1999-2007) were reviewed. N-acetylcysteine (NAC) is an antioxidant agent replenishes the intracellular gluthathione stores. However, the literature concerning human endosulfan exposure is limited to case reports. Sixteen (30.7%) of the 52 patients died, and 48 patients experienced seizures. Prophylactic anticonvulsant therapy for symptomatic patients and aggressive treatment for seizures … If released to air, a vapor pressure of 1.0X10-11 mm Hg at 25 °C indicates endosulfan sulfate will exist in … 2013 May;24(3):592-3. PMID: 19152551 [Indexed for MEDLINE] Publication Types: Case Reports At the gross examination of the brains, marked hyperemia at the meningeal ve ssels and slight hemorrhages in brains and cerebellums in rabbits suffer from endosulfan poisoning were reported. Taurine has been found to be linked to membrane stabilization, calcium homeostasis and osmoregulation ; down-regulation of this amino acid may contribute to the partial cell repolarization that causes muscle cramps and convulsions, symptoms that are common in an endosulfan poisoning event. BETA-ENDOSULFAN is a sulfite ester of a chlorinated cyclic diol. J Clin Neurosci. BETA-ENDOSULFAN is a sulfite ester of a chlorinated cyclic diol. Your treatment partly depends on what gave you food poisoning and how sick you are. One such insecticide is endosulfan (6,7,8,9,10,10- hexachloro 1,5,5a,6,9,9a-hexahydro-6-methano-2,4,3-hexadithioxanthiepin 3-oxide), and has been widely used in agriculture since 1960. To prevent death and to accelerate improvement, the organs that suffer the most histopathological injury should be considered first and early and intensive supportive treatment should be initiated. Karatas AD, Aygun D, Baydin A. Characteristics of endosulfan poisoning: a study of 23 cases. In its Kasaragod estate alone, the Plantation Corporation sprayed 31510 litres of endosulfan between 1990 and 2000. The suspected mechanism of hepatic injury appears to be similar to that of APAP and the empiric use of NAC may be justified, especially in significant endosulfan poisoning. To prevent death and to accelerate improvement, the organs that have more apparent histopathological injury should be considered and early and intensive supportive treatment be initiated. ";s:7:"keyword";s:30:"endosulfan poisoning treatment";s:5:"links";s:988:"Dynamics And Control Book,
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