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Clinical and physiologic implications. Recent progress in research on parathyroid hormone (PTH) biosynthesis has been marked by the identification, isolation, and structural characterization of two distinct biosynthetic precursors of the hormone (Habener, 1976 ; Habener and Potts, 1976a).

Furthermore, the parathyroid hormone liberated into the culture medium from parathyroid glands incubated in vitro resembled that of serum rather BIOSYNTHESIS OF PARATHYROID HORMONE 201 than the hormone extracted from the gland. Biosynthesis of parathyroid hormone. Heterogeneity of parathyroid hormone. Potts JT Jr, Kronenberg HM, Habener JF, Rich A. Figure 11 summarizes our present concepts of the biosynthetic sequence for parathyroid hormone, deduced largely from observations in vitro. [PMC free article] Silverman R, Yalow RS. 1971 Dec; 68 (12):2986–2991. Within 1 min of synthesis, the polypeptide, proparathyroid hormone (ProPTH), is formed as a result of the proteolytic removal of the NH2-terminal 25 amino acids from Pre-ProPTH. J Clin Invest.
Habener JF, Powell D, Murray TM, Mayer GP, Potts JT., Jr Parathyroid hormone: secretion and metabolism in vivo.

This led to the postulate of a 'glandular' and a 'secreted' form of PTH, the former being a precursor of the latter. After a delay of 15-20 min, the NH2-terminal six-amino acid sequence of … 1973 Aug; 52 (8):1958–1971.

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